Blar i forfatter "Kristoffersen, Tone"

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    • 3,4-Dihydroquinoxalin-2-ones: recent advances in synthesis and bioactivities 

      Kristoffersen, Tone; Hansen, Jørn H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-26)
      A summary of recent synthesis approaches to 3,4-dihydroquinoxaline-2-ones is discussed herein along with highlights of biological activity. The synthetic approaches include access to enantiopure heterocycles from chiral pool amino acids via coupling/cyclization, Michael addition/cyclization cascades, 3,3-disubstituted systems from multicomponent couplings, Bargellini reaction or photochemical ...

    • Bacterial extracellular vesicles: towards realistic models for bacterial membranes in molecular interaction studies by surface plasmon resonance 

      Brilkov, Maxim; Stenbakk, Victoria; Jakubec, Martin; Vasskog, Terje; Kristoffersen, Tone; Cavanagh, Jorunn Pauline; Ericson, Johanna Ulrica; Isaksson, Johan Mattias; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-13)
      One way to mitigate the ongoing antimicrobial resistance crisis is to discover and develop new classes of antibiotics. As all antibiotics at some point need to either cross or just interact with the bacterial membrane, there is a need for representative models of bacterial membranes and efficient methods to characterize the interactions with novel molecules -both to generate new knowledge and to ...

    • Can the absolute configuration of cyclic peptides be determined with vibrational circular dichroism? 

      Eikås, Karolina Di Remigio; Monika, Krupová; Kristoffersen, Tone; Beerepoot, Maarten; Ruud, Kenneth (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-16)
      Cyclic peptides show a wide range of biological activities, among others as antibacterial agents. These peptides are often large and flexible with multiple chiral centers. The determination of the stereochemistry of molecules with multiple chiral centers is a challenging and important task in drug development. Chiroptical spectroscopies such as vibrational circular dichroism (VCD) can ...

    • Goldilocks Dilemma: LPS Works Both as the Initial Target and a Barrier for the Antimicrobial Action of Cationic AMPs on E. coli 

      Jakubec, Martin; Rylandsholm, Fredrik G.; Rainsford, Philip; Silk, Mitchell; Bril'kov, Maxim; Kristoffersen, Tone; Juskewitz, Eric; Ericson, Johanna U; Svendsen, John Sigurd Mjøen (Journal article; Tidsskriftartikkel, 2023-07-20)
      Antimicrobial peptides (AMPs) are generally membrane-active compounds that physically disrupt bacterial membranes. Despite extensive research, the precise mode of action of AMPs is still a topic of great debate. This work demonstrates that the initial interaction between the Gram-negative E. coli and AMPs is driven by lipopolysaccharides (LPS) that act as kinetic barriers for the binding of AMPs to ...

    • Microwave-assisted synthesis of heterocycles from aryldiazoacetates. 

      Kristoffersen, Tone (Master thesis; Mastergradsoppgave, 2017-11-15)
      A novel microwave-assisted method for generation of heterocycles have been explored. A range of 3,4 dihydroquinoxalin-2-ones have been prepared via an N-H insertion/cyclization cascade of dinucleophiles and aryldiazoacetates in moderate to good yields (12 - 80%). Reactions of aryldiazoacetates with o-phenylenediamine generated the best yields, while reactions with aliphatic and benzylic dinucleophiles ...

    • Microwave‐Assisted Synthesis of Heterocycles from Aryldiazoacetates 

      Kristoffersen, Tone; Elumalai, Vijayaragavan; Starck, Eliot; Cousin, Étienne; Hansen, Stephanie Ramona; Hansen, Jørn H (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-17)
      Herein, we describe a rapid microwave-assisted, metal-free synthesis of substituted quinoxalinones and quinoxalines using the carbene-mediated reaction between aryldiazo esters and 1,2-diamines. The reaction can encompass a range of substituents and structural variations to afford quinoxalin-2-ones in 14–80 % yield and corresponding quinoxalines in good to excellent yields upon oxidation (67–96 %). ...